Matrix revolutions in 3D

Oogenesis: Matrix Revolutions

The mechanism of egg-chamber elongation during Drosophila oogenesis has always been mysterious. A new study shows that the egg chambers spin around their long axis laying down polarised extracellular matrix, which acts as a molecular corset to restrict radial expansion.

The matrix revolutions: matrix metalloproteinase, vasculogenesis, and ischemic tissue repair.

The matrix metalloproteinase (MMP) family of Zinc dependent extracellular proteinases regulates development and physiologic events, including branching morphogenesis, angiogenesis, wound healing and extracellular matrix degradation. They are synthesized as secreted or transmembrane proenzymes and processed to an active form by the removal of an amino-terminal propeptide. MMP-2/Gelatinase A, as ...

Technological Revolutions

In skill-biased (de-skilling) technological revolutions learning investments required by new machines are greater (smaller) than those required by preexisting machines. Skill-biased (de-skilling) revolutions trigger reallocations of capital from slow(fast-) to fast(slow-) learning workers, thereby reducing the relative and absolute wages of the former. The model of skill-biased (de-skilling) re...

Philosophical Revolutions

Revolutions in Neuroscience: Tool Development

Thomas Kuhn's famous model of the components and dynamics of scientific revolutions is still dominant to this day across science, philosophy, and history. The guiding philosophical theme of this article is that, concerning actual revolutions in neuroscience over the past 60 years, Kuhn's account is wrong. There have been revolutions, and new ones are brewing, but they do not turn on competing p...